Older patients who took the antibiotic combination trimethoprim-sulfamethoxazole, or TMP-SMX, for a urinary tract infection while they were on beta-blocker therapy had an increased risk of elevated potassium levels, according to a Canadian study. Researchers found that the risk of severe hyperkalemia was five times higher in patients who received TMP-SMX compared to those who were given amoxicillin.

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