5/31/2011

Researchers have designed an antibody that blocks the beta-secretase 1 enzyme, which plays a role in the formation of amyloid beta proteins that can lead to Alzheimer's disease, while targeting transferrin receptors. The receptors carry iron across the blood-brain barrier with antibodies attached, and they fall off of the receptors after entering the brain. Tests on mice showed that the antibodies that entered the brain helped lower amyloid beta protein levels, according to the findings published in the journal Science Translational Medicine.

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