Targeting CD47, a cell-surface protein that is highly expressed by cancer cells, could allow clinicians to distinguish benign and malignant bladder tumors and facilitate more precise surgical treatment, according to a study in the journal Science Translational Medicine. Researchers showed that fluorescent tagging of antibodies that bind to CD47 could be used to flag malignant tissue with confocal endomicroscopy and blue light cystoscopy. The sensitivity of the technique was 82.9% and specificity was 90.5%.
Boston researchers said giving acid suppressing medication to hospital patients who are not critically ill may reduce cases of gastrointestinal bleeding. Guidelines do not recommend using the drugs routinely because there is a low rate of GI bleeding in hospital settings, but researchers said it was important to identify risk factors that may warrant treatment, such as age, male gender, liver disease, renal failure, sepsis and use of preventive anticoagulants.
Researchers found that as many as 60% of college athletes in high-intensity sports -- namely crew, lacrosse and swimming -- suffered one or more symptoms of gastrointestinal disorders, such as diarrhea and abdominal pain, compared with 50% of nonathletes and less than 35% of athletes who played other sports. "The mechanics and aerobic dynamic of the highest intensity sports may cause functional GI disorders," said Dr. Asyia Ahmad.
South Korean researchers found no significant difference in the diagnostic accuracy of FDG-PET/CT and MRI in distinguishing between malignant and benign soft-tissue tumors. However, MRI posted greater positive predictive value and specificity than FDG-PET/CT when examining bone tumors.