Researchers using PET have found that exposure to secondhand smoke can raise plasma nicotine levels in the brain, as well as nicotine receptor occupancy, that will make it harder for smokers to stop the habit. "This mechanism may explain why adult smokers exposed to multiple sources of SHS [secondhand smoke] have difficulty initiating and maintaining abstinence compared with smokers without such exposure," writes lead author Arthur Brody in the Archives of General Psychiatry.

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