Data on 100,000 patients with diabetes found that those taking Takeda Pharmaceutical's Actos and GlaxoSmithKline's Avandia drugs were three to six times more likely to develop disease-related macular edema. Patients with poor glycemic control and a history of macular edema should avoid the drugs as the eye disease may lead to eventual blindness, researchers wrote in the study that was to be presented Sunday at a meeting of the American Diabetes Association.

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