Data from the Nurses' Health Study indicated that women who suffered depression had a 29% increased risk of stroke compared with women who had never been depressed. The risk for stroke was 39% higher among women who took selective serotonin reuptake inhibitors than for women who had never taken antidepressants or reported being depressed, according to data published in Stroke: Journal of the American Heart Association. Researchers said that the difference in risks for depressed women who had taken SSRIs and those who hadn't was not statistically significant.

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