A heat shock protein that dermal fibroblasts and keratinocytes secrete after injury removes a natural barrier and allows reparative dermal cells to migrate into a wound, encouraging repair and revascularization, according to a study published in Journal of Clinical Investigation. Researchers found that wounds healed faster after applying a single topical dose of a functional heat shock protein fragment that overrode a natural barrier to dermal fibroblasts and microvascular endothelial cells. In comparison, becaplermin gel therapy had limited success in promoting closure of acute wounds, the researchers said.

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