Cornell researchers have corrected cleft lip by genetically altering mice embryos, marking the first successful pre-clinical treatment for the common human genetic defect. They found that cleft lip and cleft palate occur when multiple gene mutations exist in conjunction with a defective embryogenic protein pathway. When scientists corrected the embryogenic protein problem through genetic alteration, all the mice, who were specifically bred to have cleft lip, were born with completely normal facial anatomy.

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