A high failure rate of the 40 most common initial antibiotic therapies for acute bacterial skin and skin structure infections results in longer hospital stays, higher costs and a higher mortality rate, according to a retrospective study presented at the Infectious Diseases Society of America's annual meeting. The study of 3,535 patients found initial treatment failed 22.5% of the time, with vancomycin the most frequently used treatment. Older age, peripheral vascular disease, septicemia/bacteremia, leukopenia, uremia and recent prior hospitalization were risk factors for initial treatment failure, the lead author said.

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