Insomnia and depression often occur together and most sleeping medications illicit undesirable side effects such as addiction and cognitive problems, but in an unexpected finding, researcher Gabriella Gobbi found a drug that provides longer, better-quality sleep in mice without the untoward side effects. In an unconventional discovery, Gobbi found that the two known melatonin receptors previously thought to act in a synergistic manner actually have opposing roles in the sleep cycle.

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