Researchers at the University of Texas Southwestern Medical Center found that exercise helped reverse blood glucose abnormalities in control mice on a high-fat diet, whereas autophagy-deficient mice did not show the same benefits from physical activity. The results in the journal Nature suggest that autophagy, in which a cell degrades damaged or unneeded parts of itself to produce energy in response to hunger, may play a key role in how exercise protects against diabetes, researchers said.

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