A study in Diabetes revealed that mice engineered to lack the c-MET cell surface receptor had proper beta cell function and blood glucose levels within the normal range. However, researchers found that during pregnancy, the mice developed lower plasma insulin levels, higher blood glucose levels and reduced beta cell mass. "These findings provide the first direct evidence that HGF/c-MET signaling pathway has an important role in maternal beta cell adaptation during pregnancy," said senior investigator Adolfo Garcia-Ocana.

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