E15 is cleared by the Environmental Protection Agency for use in vehicle model years 2001 and newer, as well as in all flex-fuel vehicles, writes Ben Wojdyla in a list of E15 facts. Although some industries urge caution over the use of E15, a Kettering University study found it safe in all cars from the 1995 model year forward, Wojdyla notes. Many carmakers do not issue warranty coverage for any damage linked to E15, but General Motors and Ford Motor have certified their vehicles for E15 use starting with the 2012 and 2013 model years, respectively, Wojdyla states.

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