The Michael J. Fox Foundation for Parkinson's Research awarded Rhythm Pharmaceuticals a $1.4 million grant to support a midstage study of ghrelin agonist RM-131, its drug candidate for refractory constipation, which affects many Parkinson's disease patients. "As we continue our work to advance RM-131 in the clinic, we are excited to join with The Michael J. Fox Foundation to address this important unmet need in Parkinson’s disease," Rhythm CEO Keith Gottesdiener said.
Lubiprostone has gained widened FDA approval, making it the first oral therapy approved for opioid-linked constipation in adults who have chronic, noncancer pain. The drug was previously approved for chronic idiopathic constipation among adults and constipation associated with irritable bowel syndrome in adult women.
The number of mothers in Alaska who said they chose to delay or not give their children the recommended vaccines rose from 23.8% in 2009 to 33.2% in 2011, according to the Alaska Childhood Understanding Behaviors Survey. Of the "vaccine hesitant" respondents, nearly 44% said vaccines were administered too early and 28% said they were concerned that the shots would be more harmful than beneficial.
Patients taking a proton pump inhibitor had higher rates of Campylobacter and Salmonella infections than those not on the drugs, but data show they also were at higher risk for infection before beginning the medication, researchers reported in The American Journal of Gastroenterology. Researchers from Swansea University in the U.K. said infection risks increased over time for all patients. "Thus, increases in [gastrointestinal] infection after a PPI prescription are likely to be owing to a general increase in infection diagnosis rather than a result of the PPI prescription," according to the researchers.
People who made dietary and exercise changes together did a better job meeting nutrition and activity goals than those who made the changes separately or did not make changes at all, Stanford University researchers reported. Registered dietitian Felicia Stoler says people would rather change what they eat than change their exercise, but those who become more physically active tend to feel better about themselves, and dietary improvements often follow.