A Journal of Nuclear Medicine study that used SPECT imaging with I-123 PE21 found that binding of the tracer to the dopamine transporter system did not show a clear link with signs of Lewy body dementia. "Our results suggest that the general level of cognitive impairment in DLB patients is not influenced by striatal dopaminergic dysfunction," researchers said. However, they noted more research is needed to substantiate their findings.

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