Three reports in The Lancet focus on issues surrounding blood transfusions. One study found variation in transfusion rates among hospitals. Dr. Lawrence Goodnough of Stanford University and co-authors cite evidence that supports restrictive transfusion practices. Another report outlines alternatives to allogeneic blood transfusions, including erythropoiesis-stimulating agents, hemostatic agents and autologous blood procurement. The third report highlights challenges relating to the blood supply.