Four tigers at the In-Sync Exotics Wildlife Rescue and Educational Center in Wylie, Texas, have been diagnosed with canine distemper and another 18 lions and tigers have displayed signs of the highly contagious virus that typically infects dogs, raccoons and other smaller species. Signs of illness among the big cats include lethargy, respiratory problems and a reluctance to eat. "There's not a lot of research out there, so we don't know what to expect. We can't treat the virus. All we can do is give them antibiotics to try to treat the secondary infections and of course supplements and vitamins," said spokeswoman Lisa Williams.