Insulin-treated type 1 diabetes patients who received the experimental vaccine TOL-3021 once weekly showed increased C-peptide levels and attained reductions in T-cell rates, according to a study in Science Translational Medicine. The vaccine also helped preserve some remaining beta cells in patients at 12 weeks without side effects, researchers noted.
Roche Holding and AstraZeneca will contribute data to MedChemica, which analyzes chemical compounds for potential safety or efficacy problems. The companies will share certain details about chemical compounds they have developed and the results of tests on the compounds.
The Bill & Melinda Gates Foundation announced plans to match two-to-one each dollar Rotary International raises for a polio eradication initiative, up to $35 million annually for the next five years. Polio remains endemic only in Pakistan, Afghanistan and Nigeria, but the virus may be resurging in the Horn of Africa, and polio vaccinators have been killed recently.
The NIH's Clinical and Translational Science Awards program, now operating within the National Center for Advancing Translational Sciences, has made translational research a focal point for academic researchers and has the potential to catalyze further progress, an Institute of Medicine report found. The IOM recommends that CTSA researchers engage in more collaborations, develop and disseminate innovative research resources, and build on successes.
The Translational Genomics Research Institute and Ventana Medical Systems have entered a partnership to research new biomarkers for diagnosis, assessment and treatment of pancreatic cancer. The collaboration aims "to rapidly translate basic research findings into actionable targets," said TGen President and Research Director Jeffrey Trent.