Patients diagnosed with Clostridium difficile infection who have taken statin drugs may have a better chance of seeing improvement with treatment. Researchers from South Korea also found the lack of a nasogastric tube, lower creatinine levels, higher albumin and milder severe symptoms were linked with treatment efficacy.
A study of almost 3,000 inpatients in the U.K. ages 65 and older who had been or were to be given antibiotics found 10.8% of those who took probiotics developed antibiotic-associated diarrhea and C. difficile-associated diarrhea, compared with 10.4% of those who received a placebo. U.S. gastroenterologist Fabio Cominelli commented that more research is needed before giving up on probiotics to prevent diarrhea because the study did not test for probiotic DNA in stool samples before and after therapy.
Bariatric surgery can affect the expression of genes in the liver, which could help explain post-procedure metabolic effects, such as a reversal of symptoms in nonalcoholic fatty liver disease, according to research from University Hospital Dresden in Germany. Liver biopsies before and after surgery found DNA methylation was changed for some loci among patients with NAFLD.
Colitis that occurs following a transplant of cord-blood stem cells may be caused by a novel bacterium, according to Dana-Farber Cancer Institute researchers who performed genetic sequencing of colon biopsies. The study did not demonstrate a causal relationship between Bradyrhizobium enterica and cord colitis but hematologist William Hogan of Mayo Clinic in Rochester, Minn., said if confirmed, the findings will make diagnosis of diarrhea after transplantation a little easier.
U.K. study data reported in The Lancet said adding cetuximab to standard treatment with oxaliplatin and capecitabine for advanced colorectal cancer increased response rates but not progression-free or overall survival. A second study track found using planned treatment holidays during initial chemotherapy did not affect survival rates.