Interpretation of F-18 labeled fluorothymidine and fluoromisonidazole scans needs some work, according to a study in the Journal of Nuclear Medicine that found low reader agreement on tumor volume. Researchers in France conducted PET/CT using F-18 labeled agents FDG, FLT and FMISO in patients with non-small-cell lung carcinoma. "This study showed excellent reproducibility of the analysis of F-18 FMISO and F-18 FLT PET/CT images when the images were analyzed using binary scales. This reproducibility allows for the use of these images in multicenter studies. In contrast, the poor reproducibility of the delineation of hypoxia and proliferative volumes requires great caution about their use for the management of patients and for therapeutic decision-making," researchers said.

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