A study of almost 3,000 inpatients in the U.K. ages 65 and older who had been or were to be given antibiotics found 10.8% of those who took probiotics developed antibiotic-associated diarrhea and C. difficile-associated diarrhea, compared with 10.4% of those who received a placebo. U.S. gastroenterologist Fabio Cominelli commented that more research is needed before giving up on probiotics to prevent diarrhea because the study did not test for probiotic DNA in stool samples before and after therapy.

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