Researchers at the University of Jordan in Amman have used gas chromatography to measure the presence of azelaic acid, a byproduct of fatty acid oxidation, in skin cream. The results for three commercial creams tested indicate the presence of the acid could be used as an indicator of skin cream stability. The researchers also tested two derivatization procedures since derivatization is required to analyze the fatty acids with GC, choosing dimethyl ester over trimethylsilyl ester because of stability concerns with the latter.

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