A growing number of physicians and researchers say gastrointestinal bacteria may play a role in diagnoses such as anxiety, obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Some studies have focused on high levels of the metabolite HPHPA, a byproduct of the clostridia bacterium that is linked to dopamine regulation. "The gut bacteria talk to the brain in multiple ways through either the immune system or the enteric nervous system," said McMaster University professor Jane Foster.
Data from more than 77,000 obese people in Sweden found obesity surgery was linked with a higher risk of colorectal cancer over the long term, researchers reported. They said the findings suggest a need to consider colonoscopy screening for patients who have obesity surgery.
A review of 10 clinical trials found antibiotics led to higher breath test normalization rates, when compared with a placebo, for patients with small intestinal bacterial overgrowth. Researcher Dr. Justin Sewell of the University of California, San Francisco, said antibiotics appear to be useful for eradicating SIBO, but sample sizes and trial design prevented the study team from finding an "ideal" treatment strategy.
A population-based study found the anti-obesity drug orlistat does not appear to raise the short-term risk of colorectal cancer, according to researchers at the University of North Carolina at Chapel Hill. They cautioned, however, that because of study limitations, the possibility that long-term use of orlistat may raise CRC risk cannot be excluded.
A study of patients ages 50 to 75 found no significant association between having had a prior endoscopy and the chances of detecting sessile serrated polyps, possibly because the flat polyps are more difficult to find, researchers from Fred Hutchinson Cancer Research Center reported. The study in the American Journal of Gastroenterology did link a prior endoscopy to a lower overall likelihood of detecting colorectal polyps, whether from colonoscopy or sigmoidoscopy.