PET imaging using Pittsburgh Compound B suggests beta amyloid buildup is associated with sleep duration and quality. PiB-PET scans were performed in 3D mode after a mean intravenous bolus injection of 540 MBq of PiB in 70 adult patients to measure beta amyloid burden in the cortical and precuneus regions of the brain. The findings, published in JAMA Neurology, showed that patients with shorter sleep duration and lower sleep quality had greater beta amyloid burden, but further studies are needed to determine whether these factors are involved with the development of Alzheimer's disease.

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