STEMI patients who received metoprolol before undergoing primary PCI experienced smaller infarcts and higher left ventricular ejection fractions, according to data published in Circulation. "Infarct size is a major determinant of post-infarction mortality," the researchers wrote. "... Here, we show that an inexpensive medication already approved for STEMI treatment ... can significantly reduce infarct size simply by being administered before reperfusion."

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