A new compound stopped brain cell death in mice models with prion disease by blocking the enzyme PERK, which is essential in activating a natural defense mechanism that regulates production of brain proteins. The defense mechanism is overactivated when beta amyloid accumulates in the brain, preventing the production of protective proteins. The study, published in the journal Science Translational Medicine, offers a possible route to pursue in development of treatment for neurodegenerative illnesses such as Alzheimer's disease or Parkinson's disease.

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