Brain scans that tracked the clinical effects of pregabalin, used to treat fibromyalgia, show it may work by lowering glutamate concentrations in the insula, the part of the brain linked to processing pain and emotion, University of Michigan researchers reported. The study found glutamate reductions were tied to decreases in insula connectivity and pain ratings. "The results could point to a future in which more targeted brain imaging approaches can be used during pharmacological treatment of chronic widespread pain, rather than the current trial-and-error approach,” said lead author Richard Harris.

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