A primary barrier to a cure for HIV infection is a pool of infected memory T cells that remains remarkably stable during long-term combinational antiretroviral therapy, said researchers in a study to be published in the Proceedings of the National Academy of Sciences. The investigators further found that the frequency of T cell HIV-1 infection was lower in patients who began HIV treatment early, indicating that the early initiation of therapy results in smaller HIV-1 reservoirs in these cells.

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