Perfusion-based functional MRI with a 4-tesla arterial spin labeling protocol showed Alzheimer's disease patients have increased perfusion or greater activation in areas of the brain such as the bilateral prefrontal cortex, dorsolateral and ventrolateral prefrontal cortex and anterior cingulate cortex compared with healthy controls while performing encoding and retrieval tasks. Results presented at a radiology meeting suggest that patients with early AD show hyperactivation in specific areas of the brain because they needed increased focus in completing memory tasks, a neurocompensatory response clearly shown using fMRI.

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