Physicians have had a couple of months to study or implement new cholesterol guidelines that drop the use of low-density lipoprotein targets, and they are starting to voice their opinions on the changes. Stanley Hazen, a physician at the Cleveland Clinic, said the new guidelines ignore large amounts of data on the pathophysiology of the disease process, and James de Lemos, a physician at the University of Texas Southwestern Medical Center, said primary care physicians may be hesitant to adopt the guidelines because they are a "massive paradigm shift that dramatically changes the approach to disease."

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