Patients with acute upper respiratory tract infections who take warfarin had a more than twofold higher risk of excessive anticoagulation, regardless of whether they were treated with antibiotics, according to a study in JAMA Internal Medicine. The risk of excessive anticoagulation, however, was significantly higher among those taking metronidazole, trimethoprim-sulfamethoxazole, or other antibiotics that interfere with the body's processing of warfarin.

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