Congenital cytomegalovirus (cCMV) infection is the most common congenital viral infection, affecting 20,000 to 40,000 infants in the United States annually. However, not all symptomatic infants are recognized to have cCMV in the nursery, because findings at birth sometimes are subtle and nonspecific. Two or more clinical findings were detected at birth in 91% of referred infants and only 58% of screened infants (P < .001). Infants with symptomatic cCMV identified based on clinical suspicion have more severe disease at birth and more commonly have sequelae than those identified on newborn screening.

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