University of Michigan researchers have uncovered the mechanism behind Golgi apparatus damage that is associated with Alzheimer's disease development, and they hope to use that information to stem the development of the disease. Beta amyloid peptide accumulation induces an enzyme that damages a key Golgi protein. They found that inhibiting the enzyme or expressing a form of the Golgi protein that resists damage could reduce beta amyloid secretion, according to details in the Proceedings of the National Academy of Sciences.

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