Young adults with high fasting blood glucose levels and hypertension are more likely to experience cognitive decline in middle age, according to a study in the journal Circulation. "We already know that reducing these risk factors in midlife can decrease the risk of dementia in old age," said researcher Dr. Kristine Yaffe. "If it turns out that the damage begins before middle age, we may need to expand our focus and work on reducing heart disease risks in earlier stages of life." The study authors said cardiovascular risk factors could affect blood supply to the brain, inflammation and oxidative stress and may hinder amyloid protein clearance.

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