Epidermal p53 expression was reduced and procollagen I levels were increased after photodamaged forearm skin was treated with either weekly peels or daily application of 5% fluorouracil, researchers report in the journal Dermatologic Surgery. Patients applied 5% 5-fluorouracil cream each night for 28 nights on one forearm and on the other received four weekly peels with a combination of Jessner's solution and 5% 5-FU in propylene glycol. Researchers reported no differences between the two treatments for any of the clinical parameters evaluated.

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