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Old drug for horses breaks through MRSA cells

Bithionol, an old drug for treating parasitic infections in horses, penetrates the membrane of methicillin-resistant Staphylococcus aureus and killed persistent MRSA in a lab dish within 24 hours, researchers reported in Proceedings of the National Academy of Sciences. Computer simulations demonstrated that the drug does not penetrate mammalian cells, and killed 90% of MRSA infections in mice when combined at a low dose with gentamicin.

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