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Study compares effect of lifestyle changes, medications on diabetes risk

Researchers conducted a meta-analysis of 43 randomized clinical trials including 49,029 participants and found that lifestyle modification studies showed a 39% reduction in the relative risk of diabetes, compared with a 36% reduction in studies of medications and a risk difference of 4.0 cases per 100 person-years in studies involving both lifestyle modification and medications. The findings in JAMA Internal Medicine revealed that diabetes risk was reduced by 28% in lifestyle modification studies at the end of follow-up, while risk reduction was not sustained in studies of medications after therapy was discontinued by patients.

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