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Study links spontaneous beta-amyloid, tau chemistry to Alzheimer's

University of California at Riverside researchers who used liquid chromatography and mass spectrometry found that beta-amyloid and tau proteins associated with Alzheimer's disease underwent spontaneous isomerization and epimerization that prevent them from being broken down by lysosomal enzymes, resulting in lysosomal storage, and people with lysosomal storage disorders had failed lysosomal body storage, plaque buildup and neurofibrillary tangle formation similar to those with Alzheimer's. The findings in ACS Central Science may prompt new Alzheimer's treatments, researchers said.

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