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Study examines hypoglycemia risk during insulin titration

Researchers used a cohort of 3,549 patients with type 2 diabetes and found an increased risk for hypoglycemic events when titration with insulin glargine 100 U/mL was added to sulfonylurea in patients with low body mass index or low levels of fasting C-peptide, prior to starting basal insulin. The findings, published in Diabetes, Obesity and Metabolism, showed that "people with greater insulin resistance may benefit from the addition of [glargine 100 U/mL] to an oral regimen consisting of metformin, while avoiding sulfonylurea-based regimens and/or withdrawing sulfonylurea when basal insulin is initiated."

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