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Research examines effects of circadian system, misalignment on insulin

Researchers evaluated 14 healthy adults for impacts of the circadian system, behavioral cycles and their interaction on beta-cell function and insulin insensitivity and found that the circadian system mainly decreased static and dynamic beta-cell responsivity to lower glucose tolerance in the biological evening, compared with the biological morning. Circadian misalignment lowered insulin sensitivity to reduce glucose tolerance but did not affect beta-cell function, according to the findings in Diabetes, Obesity and Metabolism.

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