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Study links insulin resistance to diabetes patients' DPP-4 inhibitor response

UK researchers found that type 2 diabetes patients with several markers of higher insulin resistance -- such as higher fasting C-peptide, triglycerides and homeostatic assessment model of insulin resistance-2 -- experienced a reduced A1C response to DPP-4 inhibitors at six months, compared with those with less insulin resistance. The findings in Diabetes Care, based on data from 254 diabetes patients not treated with insulin and EMRs of 23,001 patients, also revealed an association between response to DPP-4 inhibitors and higher body mass index and triglyceride levels.

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