Researchers who used PET found that the novel tau radiotracer F-18-RO-948 was the most promising in tau imaging, as it yielded the highest standardized uptake value across brain regions of individuals with and without Alzheimer's disease and also had improved contrast between brain regions with high and low tau accumulation, compared with novel tracers C-11-RO-643 and C-11-RO-963. The findings in the Journal of Nuclear Medicine also showed that those with Alzheimer's had significantly different F-18-RO-948 binding in various brain areas, as well as higher tracer binding in a set of symmetric clusters, compared with healthy controls.
PET study compares breakthrough tau tracers in Alzheimer's
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