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Microglial cell memory may prompt Alzheimer's disease

German researchers found that mouse models with microglia immune cells "trained" by an initial inflammatory stimulus to have a stronger response to another inflammatory stimulus, indicating microglial memory of previous inflammation, had increased amyloid plaque production associated with Alzheimer's disease, but those that became inflammation-tolerant after a fourth stimulus had reduced amyloid accumulation. The findings in the journal Nature also showed epigenetic changes in both trained and tolerant microglia, prompting researchers to suggest that inflammatory diseases occurring outside the brain may spur epigenetic reprogramming within the brain.

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