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Elevated Z drug doses up adverse events in dementia

People with dementia who started on higher doses of Z drugs, such as zaleplon, zolpidem and zopiclone, for sleep disturbance were significantly more likely to develop fractures, hip fractures, ischemic stroke and falls, compared with those who didn't use sedatives, researchers reported in the journal BMC Medicine. They also had increased odds of hospital admission, general practitioner visits, and antibiotic, antidepressant and antipsychotic prescriptions. However, the findings showed that lower Z drug doses also correlated with "minimal or inconsistent" excess adverse outcome risk.

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