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Targeting senescent brain cells may curb tau pathology, memory loss

Mayo Clinic researchers found that mice with tau protein tangles associated with Alzheimer's disease had senescent microglia and astrocytes in brain regions involved in cognition and memory prior to cognitive decline, but they no longer had tau protein accumulation and inflammation symptoms after receiving treatment with a genetically modified enzyme targeted to remove senescent cells. The findings, which also documented reduced neuronal death and memory loss, were published in the journal Nature.

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