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Capillary constriction linked to cognitive decline in Alzheimer's

Human brain tissue with Alzheimer's disease and mouse models with Alzheimer's-associated amyloid-beta protein had constricted capillaries, reducing blood flow similar to levels observed in other brain regions affected by Alzheimer's, according to a UK study in the journal Science. The findings prompted researchers to suggest that capillary constriction, which hampers delivery of oxygen and glucose to the brain, could be associated with Alzheimer's-related cognitive decline.

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