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Study examines proton beam radiotherapy in brain, intellectual outcomes

Children with medulloblastoma who received proton beam radiotherapy had much better scores for working memory, global intelligence quotient and perceptual reasoning, compared with those who received traditional photon therapy, according to a Canadian study in the Journal of Clinical Oncology. The study, based on 79 children who underwent radiotherapy between 2007 and 2018, found that "with less irradiation of healthy cerebellar tissue, cognitive outcomes improve, likely due to reduced white matter damage allowing for preserved or more recoverable cerebrocerebellar connections," said study author Don Mabbott.

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