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PET sheds light on gene transcription dysregulation in schizophrenia

Researchers who used PET with the radiotracer Martinostat found that individuals with schizophrenia or schizoaffective disorder had significantly reduced expression of the gene transcription regulator histone deacetylase 2 enzyme in the dorsolateral prefrontal cortex, correlating with worse cognitive performance, and other adjacent brain regions, but had elevated HDAC expression in the cerebellum and cerebral white matter, compared with controls. The findings in The Journal of Clinical Investigation "will enable long-term studies exploring the relationship between HDAC levels and disease onset, progression and symptom severity," said lead researcher Tonya Gilbert.

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