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Study: Alzheimer's-linked brain changes seen before symptom appearance

A study in Frontiers in Aging Neuroscience found that adults with cognitive problems or dementia had elevated p-tau and total tau proteins associated with Alzheimer's disease in their cerebrospinal fluid an average of 13 years and 34.4 years, respectively, before cognitive impairment began, as well as slightly altered cognitive test scores at 11 years to 15 years before cognitive impairment onset. The findings suggest that CSF analysis and brain imaging may be used to provide early Alzheimer's risk assessments, said researcher Laurent Younes.

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