Researchers classified individuals with late-onset Alzheimer's disease into six subgroups, with participants in the largest group having similar memory, language, executive functioning and visuospatial functioning scores, and identified 33 single nucleotide polymorphisms that were very strongly associated with one subgroup, with the APOE e4 allele having a strong relationship with risk among those in the subgroup with significantly lower memory scores. The findings in Molecular Psychiatry may prompt the development of personalized Alzheimer's treatments, researchers said.
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